Prof. Partha P. Majumder, PhD
Director, National Institute of Biomedical Genomics (NIBG), Netaji Subhas Sanatorium, Kalyani & Professor, ISI, Kolkata, India
Talk Title: Identifying Drivers in Cancer Genomes: Computational and Statistical Challenges
Abstract: The search of genes that drive cancer is important and is now a global endeavor. The search comprises massively-parallel DNA sequencing during which very large data sets are generated. The statistical challenge that one is confronted with is to manage and find patterns in these data that are of statistical and biological significance. Several approaches are being proposed for analyses of these large data sets. We have devised a statistical methodology for detection of somatic variants. In this talk, I shall describe the expanse of the sequence data, methodologies of managing these data and the statistical methodology for variant-calling developed by us. Finally, I shall provide some relevant results of our analysis of oral cancer genomes and the implications of these findings for precision medicine.